High-Density Lipoprotein Anti-Inflammatory Capacity and Acute Kidney Injury After Cardiac and Vascular Surgery: A Prospective Observational Study.

ABSTRACT:

Objectives

Acute kidney injury (AKI) predicts death after cardiac and vascular surgery. Higher preoperative high-density lipoprotein (HDL) concentrations are associated with less postoperative AKI. In animals, HDL's anti-inflammatory capacity to suppress endothelial cell adhesion molecule expression reduces kidney damage due to ischemia and hemorrhagic shock. The objective of this study is to evaluate the statistical relationship between HDL anti-inflammatory capacity and AKI after major cardiac and vascular surgery.

Design

Prospective observational study.

Setting

Quaternary medical center.

Patients

One hundred adults with chronic kidney disease on long-term statin therapy undergoing major elective cardiac and vascular surgery.

Interventions

None.

Mea

SUBMITTER: Perkins ZM 

PROVIDER: S-EPMC11620948 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature