ICAM1⁺ gingival fibroblasts modulate periodontal inflammation to mitigate bone loss.

ABSTRACT: Tissue-resident fibroblasts are heterogeneous and provide an endogenous source of cytokines that regulate immunologic events in many osteolytic diseases. Identifying distinct inflammatory fibroblast subsets and conducting mechanistic in vivo studies are critical for understanding disease pathogenesis and precision therapeutics, which is poorly explored in periodontitis. Here, we surveyed published single-cell datasets for fibroblast-specific analysis and show that Intercellular Adhesion Molecule-1 (ICAM1) expression selectively defines a fibroblast subset that exhibits an inflammatory transcriptional profile associated with nuclear factor-κB (NF-κB) pathway. ICAM1⁺ fibroblasts expand in both human periodontitis and murine ligature-induced periodontitis model, which have u

SUBMITTER: Kim WS 

PROVIDER: S-EPMC11621011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature