Identification of early Alzheimer's disease subclass and signature genes based on PANoptosis genes.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is one of the most prevalent forms of dementia globally and remains an incurable condition that often leads to death. PANoptosis represents an emerging paradigm in programmed cell death, integrating three critical processes: pyroptosis, apoptosis, and necroptosis. Studies have shown that apoptosis, necroptosis, and pyroptosis play important roles in AD development. Therefore, targeting PANoptosis genes might lead to novel therapeutic targets and clinically relevant therapeutic approaches. This study aims to identify different molecular subtypes of AD and potential drugs for treating AD based on PANoptosis.

Methods

Differentially expressed PANoptosis genes associated with AD were identified via Gene Expression Omnibus (GEO) dataset GSE483

SUBMITTER: Wang W 

PROVIDER: S-EPMC11621049 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature