Dynamics of cytokine and antibody responses in community versus hospital SARS-CoV-2 infections.

ABSTRACT:

Introduction

Dysregulated host cytokine responses to SARS-CoV-2 infection are a primary cause of progression to severe disease, whereas early neutralizing antibody responses are considered protective. However, there are gaps in understanding the early temporal dynamics of these immune responses, and the profile of productive immune responses generated by non-hospitalized people with mild infections in the community.

Methods

Here we conducted a prospective cohort study of people with suspected infections/exposures in the US state of North Carolina, before vaccine availability. We recruited participants not only in hospitals/clinics, but also in their homes. With serial sampling, we compared virologic and immunologic factors in 258 community cases versus 114 hospital cases of

SUBMITTER: Singh T 

PROVIDER: S-EPMC11621060 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature