Total burden of cerebral small vessel disease predict subjective cognitive decline in patients with Parkinson's disease.

ABSTRACT:

Introduction

This study investigates the correlation between the total burden of Cerebral Small Vessel Disease (CSVD) and Subjective Cognitive Decline (SCD) in patients with Parkinson's disease (PD).

Methods

A cross-sectional design was employed, involving 422 patients with PD. Demographic and clinical data were collected. Brain magnetic resonance imaging (MRI) was conducted to identify CSVD markers. SCD was assessed using the Cognitive Complaints Inventory (CCI).

Results

Logistic regression analyses revealed that the total burden of CSVD and specific imaging markers, including Deep White Matter Hyperintensities (DWMH), Periventricular Hyperintensities (PVH), and Enlarged Perivascular Spaces (EPVS), were significant predictors of SCD. The total burden of CSVD demonstr

SUBMITTER: Qiu W 

PROVIDER: S-EPMC11621090 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature