Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

ABSTRACT: Research for biopharmaceutical production processes with mammalian cells steadily aims to enhance the cell-specific productivity as a means for optimizing total productivities of bioreactors. Whereas current technologies such as pH, temperature, and osmolality shift require modifications of the cultivation medium, the use of optogenetic switches in recombinant producer cells might be a promising contact-free alternative. However, the proper application of optogenetically engineered cells requires a detailed understanding of basic cellular responses of cells that do not yet contain the optogenetic switches. The knowhow of ideal light exposure to enable the optimum use of related approaches is missing so far. Consequently, the current study set out to find optimum conditions for IgG1 produci

SUBMITTER: Foller S 

PROVIDER: S-EPMC11621146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature