Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats.

ABSTRACT: Contradictory results have been reported about the effects of liver diseases on the blood-brain barrier (BBB) permeability to markers. For instance, both an increase and no change in the BBB permeability to BBB markers sodium fluorescein and Evans blue have been reported in experimental cholestasis induced by bile duct ligation (BDL) in rats. These contradictory effects might be due to inherent limitations of these markers and/or methodological issues. Here, we investigated the time course of the impact of BDL in rats on BBB permeability using a recently developed stable isotope labeled marker [¹³C]sucrose, which is expected to be devoid of limitations of other markers, such as sodium fluorescein. At various times (five days, two weeks, and four weeks) after BDL or sham surgery,

SUBMITTER: Miah MK 

PROVIDER: S-EPMC11621172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature