A case-control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE).

ABSTRACT:

Purpose

The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections.

Methods

Case-control study. Adult patients with CPE infections were considered cases, while those with non-CPE infections were controls. Matching criteria were age (± 5 years), sex, source of infection and microorganism (ratio 1:2). Primary outcome was 30-day mortality. Secondary outcomes were 90-day mortality, clinical failure, hospitalisation costs and resource consumption.

Results

246 patients (82 cases and 164 controls) were included. Klebsiella pneumoniae OXA-48 was the most common microorganism causing CPE infections. CPE cases had more prior comorbidities (p = 0.007), septic shock (p = 0.003), and were more likely to receive inappropriat

SUBMITTER: Lopez Montesinos I 

PROVIDER: S-EPMC11621180 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature