Factors predictive of recurrence, metastasis and death in node-negative penile squamous cell carcinoma: A retrospective multicentre cohort study.

ABSTRACT:

Background

Penile squamous cell carcinoma (PSCC) carries significant morbidity and mortality. Literature is limited regarding prognostic factors, especially prognostic factors for development of metastasis.

Objectives

To identify independent prognostic factors associated with poor outcomes, defined as local recurrence (LR), metastasis and disease-specific death (DSD) in clinically node-negative PSCC undergoing local therapy.

Methods

Thirty-two-year Retrospective Multicenter Cohort Study of 265 patients with histologically diagnosed PSCC at three tertiary care centres. Predictive models based on patient or tumour characteristics were developed.

Results

Local recurrence occurred in 56 patients, metastasis in 52 patients and DSD in 40 patients. In multivariable mo

SUBMITTER: O'Connell KA 

PROVIDER: S-EPMC11621226 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature