Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.

ABSTRACT:

Objective

A propensity for aggression or alcohol use may be associated with alcohol-related aggression. Previous research has shown genetic overlap between alcohol use and aggression but has not looked at how alcohol-related aggression may be uniquely influenced by genetic risk for aggression or alcohol use. The present study examined the associations of genetic risk for trait aggression, alcohol use, and alcohol use disorder (AUD) with alcohol-related aggression using a polygenic risk score (PRS) approach.

Method

Using genome-wide association study summary statistics, PRSs were created for trait aggression, alcohol consumption, and AUD. These PRSs were used to predict the phenotype of alcohol-related aggression among drinkers in two independent samples: the University of Ca

SUBMITTER: Spychala KM 

PROVIDER: S-EPMC11621227 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature