Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia.

ABSTRACT:

Background

Vein grafts are commonly employed in revascularisation surgery for multivessel coronary artery disease, yet neointimal hyperplasia (NIH) remains a critical impediment to the long-term patency of these grafts. Despite this, effective methods to precisely identify and target interventions for the neointima are still inadequate.

Methods

In this study, Sprague-Dawley (SD) rats were used to establish an external jugular vein transplantation model, and the NIH pathophysiological process was tracked across 11 time points (0-35 days) using various histological stains. Spatial transcriptomics was performed on normal veins and 19-day grafts to explore gene expression in neointimal regions. Immunohistochemical analysis identified neointima-specific markers, while NIH progres

SUBMITTER: Wang C 

PROVIDER: S-EPMC11621235 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature