MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features.

ABSTRACT:

Objective

Investigate the association between the relative tumor enhancement (RTE) of gadoxetic acid across various MRI phases and immunohistochemical (IHC) features in patients with liver metastases (LM) from colorectal cancer (CRC), breast cancer (BC), and pancreatic cancer (PC).

Methods

A retrospective analysis was conducted on 68 patients with LM who underwent 1.5-T MRI scans. Non-contrast and contrast-enhanced T1-weighted (T1-w) gradient echo (GRE) sequences were acquired before LM biopsy. RTE values among LM groups were compared by cancer type using analysis of variance. The relationships between RTE and IHC features tumor stroma ratio, cell count, Ki67 proliferation index, and CD45 expression were evaluated using Spearman's rank correlation coefficients.

Results

SUBMITTER: Barajas Ordonez F 

PROVIDER: S-EPMC11621246 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature