The Wound Reporting in Animal and Human Preclinical Studies Guidelines.

ABSTRACT: Preclinical studies for wound healing disorders are an essential step in translating discoveries into therapies. Also, they are an integral component of initial safety screening and gaining mechanistic insights using an in vivo approach. Given the complexity of the wound healing process, existing guidelines for animal testing do not capture key information due to the inevitable variability in experimental design. Variations in study interpretation are increased by complexities associated with wound aetiology, wounding procedure, multiple treatment conditions, wound assessment, and analysis, as well as lack of acknowledgement of limitation of the model used. Yet, no standards exist to guide reporting crucial experimental information required to interpret results in translational studies of

SUBMITTER: Ojeh N 

PROVIDER: S-EPMC11621255 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature