P2X ₇-receptor binding in new-onset and secondary progressive MS - a [¹¹C]SMW139 PET study.

ABSTRACT:

Background

PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at 'smoldering' lesion rims have been implicated as drivers of disability progression. The P2X ₇R is upregulated in the cellular membranes of activated microglia. A single-tissue dual-input model was applied to quantify P2X ₇R binding in the normal appearing white matter, perilesional areas and thalamus among progressive MS patients, healthy controls and newly diagnosed relapsing MS patients.

Results

Overall, tracer uptake in the MS brain was not significantly higher compared to HCs. In the 3 mm perilesional rim of all T1 lesions, tracer binding was higher among relapsing patients compared to p

SUBMITTER: Lehto J 

PROVIDER: S-EPMC11621262 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature