Sperm histone modifications may predict success in human assisted reproduction: a pilot study.

ABSTRACT:

Purpose

Currently, assisted reproduction clinics employ various sperm selection techniques to identify the best sperm for fertilization. However, these techniques may not assess crucial sperm traits that can substantially impact embryonic quality. To address this, we propose analyzing diverse histone modifications as potential markers of sperm functionality and success in assisted reproduction techniques.

Methods

Cross-sectional pilot study including infertile male patients attending an infertility clinic in CABA, Argentina between April and August 2019 was performed. We used immunofluorescence techniques to evaluate post-translational modifications of histones in sperm and established correlations with in vitro fertilization outcome and embryo quality.

Results

Our fi

SUBMITTER: Cambiasso MY 

PROVIDER: S-EPMC11621280 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature