An Inflammation-Related lncRNA Signature for Prognostic Prediction in Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) represents a commonly diagnosed malignancy affecting the digestive system. Mounting evidence shows long noncoding RNAs (lncRNAs) contribute to carcinogenesis. However, inflammation-related lncRNAs (IRLs) regulating CRC are poorly defined.

Aims

The current study aimed to develop an IRL signature for predicting prognosis in CRC and to examine the involved molecular mechanism.

Methods and results

RNA-seq findings and patient data were retrieved from The Cancer Genome Atlas (TCGA), and inflammation-associated genes were obtained from the GeneCards database. IRLs with differential expression were determined with "limma" in R. Using correlation and univariable Cox analyses, prognostic IRLs were identified. The least absolute shrinkage and

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11621381 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature