Combination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.

ABSTRACT:

Background

Neurovascular coupling (NVC) reflects the close connection between neural activity and cerebral blood flow (CBF) responses, providing new insights to explore the neuropathological mechanisms of various diseases. Non-dialysis patients with chronic kidney disease (CKD) exhibit cognitive decline, but the underlying pathological mechanisms are unclear.

Methods

The prospective study involved 53 patients with stage 1-3a CKD (CKD1-3a), 78 patients with stage 3b-5 CKD (CKD3b-5), and 52 healthy controls (HC). Our investigation involved voxel-based assessments of both global and regional BOLD signal characteristics. Additionally, we explored the correlations between neuroimaging indices, Montreal Cognitive Assessment (MoCA) scores, and clinical laboratory findings.

Resul

SUBMITTER: Song L 

PROVIDER: S-EPMC11621384 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature