Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction.

ABSTRACT: Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in AUD. This results in reduced inhibitory control of compulsive behavior and, eventually, relapse. We reasoned here that prefrontal dysfunction, which underlies vulnerability to relapse, is evidenced by altered neuroelectric signatures and should be restored by pharmacological interventions that specifically target prefrontal dysfunction. To test this, we applied our recently developed biocompatible neuroprosthesis to measure prefrontal neural function in a well-established rat model of alcohol ad

SUBMITTER: Habelt B 

PROVIDER: S-EPMC11621398 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature