Distinct Clinical Profiles of IgE and IgG Autoantibodies to Thyroid Peroxidase in Chronic Spontaneous Urticaria.

ABSTRACT:

Purpose

In chronic spontaneous urticaria (CSU), autoimmune thyroid disease is the most common autoimmune comorbidity, and many CSU patients have immunoglobulin (Ig)E or IgG autoantibodies to thyroid peroxidase (TPO). It remains unclear how anti-TPO IgE and IgG autoantibodies are linked to each other and are associated with CSU features, activity, and therapeutic responses.

Methods

CSU patients (n = 146, 92 females, mean age 42.9 years) and healthy normal controls (NCs, n = 30) were assessed for anti-TPO IgE and IgG by enzyme-linked immunosorbent assay, and the clinical and laboratory profiles, disease activity (UAS7), and response to 3 months of H1-antihistamine treatment were evaluated for anti-TPO IgE-positive and/or IgG-positive patients.

Results

Among 146 CSU pati

SUBMITTER: Jang JH 

PROVIDER: S-EPMC11621479 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature