Emotional salience network involved in constructing two-dimensional fear space in humans.

ABSTRACT: Fear learning is pivotal for organismal survival, ensuring the ability to avoid potential threats through learning based on experiencing minimal fear information. In reality, fear learning requires to form a structured representation of fear experiences from multiple dimensions in order to support flexible use in ever-changing environment. Yet, the underlying neural mechanisms of constructing dimensional fear space remain elusive. Here we set up an innovative approach with two-dimensional fear learning, by utilizing the probability (uncertainty) and subjective pain intensity of threatening mild electric shock with five levels of each dimension. Behaviorally, individuals constructed a two-dimensional fear space after learning phase, as evidenced by significant changes in participant's fearf

SUBMITTER: Lyu J 

PROVIDER: S-EPMC11621499 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature