Fractionated stereotactic radiotherapy of brainstem metastases - Clinical outcome and prognostic factors.

ABSTRACT:

Introduction

Brain metastases (BM) are the most common malignancy in the central nervous system (CNS) and observed in approximately 30% of cancer patients. Brainstem metastases (BSM) are challenging because of their location and the associated neurological risks. There are still no general therapeutic recommendations in this setting. Stereotactic radiosurgery (SRS) is one of few possible local therapy options but limited due to the tolerance dose of the brainstem. There is still no standard regarding the optimal dose und fractionation.

Methods

We retrospectively analyzed 65 patients with fractionated stereotactic radiotherapy (fSRT) for 69 BSM. FSRT was delivered at a dose of 30 Gy in six fractions prescribed to the 70 % isodose performed with Cyberknife. Overall survival (O

SUBMITTER: Kramer A 

PROVIDER: S-EPMC11621500 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature