Bioactive ECM-mimicking nerve guidance conduit for enhancing peripheral nerve repair.

ABSTRACT: Extensive research efforts are being directed towards identifying alternatives to autografts for the treatment of peripheral nerve injuries (PNIs) with engineered nerve conduits (NGCs) identified as having potential for PNI patients. These NGCs, however, may not fulfill the necessary criteria for a successful transplant, such as sufficient mechanical structural support and functionalization. To address the aforementioned limitations of NGCs, the present investigation explored the development of double cross-linked hydrogels (o-CSMA-E) that integrate the biocompatibility of porcine tendon extracellular matrix (ECM) with the antimicrobial and conductive properties of methacrylated quaternary chitosan. The hydrogels had matrices that could promote the growth of axons and the transmission of n

SUBMITTER: Liu S 

PROVIDER: S-EPMC11621582 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature