Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus.

ABSTRACT:

Backgruound

Progressive deterioration of β-cell function is a characteristic of type 2 diabetes mellitus (T2DM). We aimed to investigate the relative contributions of clinical factors to β-cell function in T2DM.

Methods

In a T2DM cohort of 470 adults (disease duration 0 to 41 years), β-cell function was estimated using insulinogenic index (IGI), disposition index (DI), oral disposition index (DIO), and homeostasis model assessment of β-cell function (HOMA-B) derived from a 75 g oral glucose tolerance test (OGTT). The relative contributions of age, sex, disease duration, body mass index, glycosylated hemoglobin (HbA1c) levels (at the time of the OGTT), area under the curve of HbA1c over time (HbA1c AUC), coefficient of variation in HbA1c (HbA1c CV), and antidiabetic agents us

SUBMITTER: Kim JY 

PROVIDER: S-EPMC11621653 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature