Dynamic pre-structuration of lipid nanodomain-segregating remorin proteins.

ABSTRACT: Remorins are multifunctional proteins, regulating immunity, development and symbiosis in plants. When associating to the membrane, remorins sequester specific lipids into functional membrane nanodomains. The multigenic protein family contains six groups, classified upon their protein-domain composition. Membrane targeting of remorins occurs independently from the secretory pathway. Instead, they are directed into different nanodomains depending on their phylogenetic group. All family members contain a C-terminal membrane anchor and a homo-oligomerization domain, flanked by an intrinsically disordered region of variable length at the N-terminal end. We here combined molecular imaging, NMR spectroscopy, protein structure calculations and advanced molecular dynamics simulation to unveil a sta

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11621693 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature