<i>Candida albicans</i> enhances <i>Staphylococcus aureus</i> virulence by progressive generation of new phenotypes.

ABSTRACT: Candida albicans and Staphylococcus aureus have been co-isolated from several biofilm-associated diseases, including those related to medical devices. This association confers advantages to both microorganisms, resulting in detrimental effects on the host. To elucidate this phenomenon, the present study investigated colony changes derived from non-physical interactions between C. albicans and S. aureus. We performed proximity assays by confronting colonies of the yeast and the bacteria on agar plates at six different distances for 9-10 days. We found that colony variants of S. aureus originated progressively after prolonged exposure to C. albicans proximity, specifically in response to pH neutralization of the media by the fungi. The new phenotypes

SUBMITTER: Arevalo-Jaimes BV 

PROVIDER: S-EPMC11621768 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature