Influence of aging and maternal protein restriction on PIWI-interacting RNA expression in the offspring rat ventral prostate.

ABSTRACT: The Developmental Origins of Health and Disease (DOHaD) concept explores the link between exposure to adverse conditions during fetal and early childhood development and the onset of chronic non-communicable diseases, such as prostate cancer (PCa). Changes in epigenetics that control gene expression have been identified as potential contributors to the developmental origin of PCa. Piwi-interacting RNAs (piRNAs), for example, control transposable elements (TEs) and maintain genome integrity in germ cells. However, stress-induced deregulation of TEs warrants investigating the role of piRNAs in the prostate gland from the DOHaD perspective, which remains underexplored. This study aimed to detect and characterize piRNA expression in the ventral prostate (VP) of Sprague Dawley rat offspring at

SUBMITTER: Baptista HS 

PROVIDER: S-EPMC11621812 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature