Protein corona formation on different-shaped CdSe/CdS semiconductor nanocrystals.

ABSTRACT: Nanoparticles (NPs) have been widely studied and applied in medical and pharmaceutical fields. When NPs enter the in vivo environment, they are covered with protein molecules to form the so-called "protein corona". Because NPs and proteins are comparable in size, the shape of NPs has a significant impact on NP-protein interactions. Although NPs of various shapes have been synthesized, how the shape of NPs affects the protein corona is poorly understood, and little is known about the underlying molecular mechanism. In the present study, we synthesized spherical, football-shaped, and rod-shaped semiconductor nanocrystals (SNCs) as model NPs and compared their interaction with human serum albumin (HSA) using fluorescence correlation spectroscopy, fluorescence quenching, Fourier-transfo

SUBMITTER: Kuroi K 

PROVIDER: S-EPMC11621831 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature