Associations between maternal gestational diabetes mellitus and offspring cerebral palsy: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies on the association between gestational diabetes mellitus (GDM) during pregnancy and pediatric neurological disorders (PNDs) such as cerebral palsy (CP), autism spectrum disorders (ASD), and epilepsy (EP) in offspring have yielded mixed findings, creating ambiguity in causal interpretations. The direct link between GDM and these PNDs remains unclear. Elucidating this connection is vital for developing effective early intervention strategies during pregnancy to mitigate the risk of PNDs in the offspring. This study utilizes a two-sample (2-sample) Mendelian randomization (MR) approach to investigate the causal relationship between GDM and its impact on CP, ASD, and EP in offspring.

Methods

We employed 2-sample MR using 6 single nucleotide polym

SUBMITTER: Peng H 

PROVIDER: S-EPMC11621887 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature