Long-term changes in the gut microbiota before and after bismuth quadruple therapy or concomitant therapy in children with peptic ulcers receiving <i>Helicobacter pylori</i> eradication.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) is a gram-negative spiral bacterium that can cause peptic ulcers. The effects of bismuth quadruple therapy and concomitant therapy on fecal ecology among children with peptic ulcers remain largely unknown. According to guidelines, these patients should be treated. Therefore, the aim of this study is to investigate the short- and long-term effects of bismuth quadruple therapy and concomitant therapy on gut microbiota in children with peptic ulcer disease (PUD).

Methods

Forty-two patients with PUD were enrolled and collected their fecal samples in Shanghai. A 16S ribosomal RNA (rRNA)-based analysis was conducted. The impacts of bismuth quadruple therapy and concomitant therapy on the gut microbiota were compared before e

SUBMITTER: He C 

PROVIDER: S-EPMC11621894 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature