Genome-wide Mendelian randomization identifies drugs associated with body height.

ABSTRACT:

Background

Mendelian randomization (MR) has been used to identify drug targets in many conditions. Height is a classic complex trait affected by genetic and early-life environmental factors. No systematic screening has been conducted to identify drugs that interact with height. We investigated the causal relationship between genes and height, and systematically screened for interactive drugs that may promote or delay growth.

Methods

We performed MR using summary statistics from the Genetic Investigation of ANthropometric Traits consortium (N=253,288), the UK Biobank (N=461,950), and the BioBank Japan Project (N=159,095). Gene expression-single-nucleotide polymorphism associations represented by cis-expression quantitative trait loci data were obtained from the Genotype-Tissu

SUBMITTER: Xi L 

PROVIDER: S-EPMC11621899 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature