The causality between gut microbiota and endometriosis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies and animal experiments had suggested a potential relationship between gut microbiota abundance and pathogenesis of endometriosis (EMs), but the relevance of this relationship remains to be clarified.

Methods

We perform a two-sample bidirectional Mendelian randomization (MR) analysis to explore whether there is a causal correlation between the abundance of the gut microbiota and EMs and the direction of causality. Genome-wide association study (GWAS) data ukb-d-N80, finn-b-N14-EM, and MiBinGen were selected. Inverse variance weighted (IVW), weighted median, and MR Egger are selected for causal inference. The Cochran Q test, Egger intercept test, and leave-one-out analysis are performed for sensitivity analyses.

Results

In the primary ou

SUBMITTER: Yang H 

PROVIDER: S-EPMC11621931 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature