Copper-Mediated -CF(OCF₃)(CF₂H) Transfer to Organic Electrophiles.

ABSTRACT: The integration of fluorine into medicinal compounds has become a widely used strategy to improve the biochemical and therapeutic properties of drugs. Inclusion of -CF₂H and -OCF₃ fluoroalkyl groups has garnered attention due to their bioisosteric properties, enhanced lipophilicity, and potential hydrogen-bonding capability in bioactive substances. In this study, we prepared a series of stable Cu[CF(OCF₃)(CF₂H)]L _n complexes by insertion of commercially available perfluoro(methyl vinyl ether), CF₂=CF(OCF₃), into Cu-H bonds derived from Stryker's reagent, [CuH(PPh₃)]₆, using ancillary ligands L. Notably, certain of these complexes effectively transfer the fluoroalkyl group to aroyl chlo

SUBMITTER: Ghaffari B 

PROVIDER: S-EPMC11621958 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature