Predictors of Death or Severe Impairment in Neonates With Hypoxic-Ischemic Encephalopathy.

ABSTRACT:

Importance

Outcomes after hypoxic-ischemic encephalopathy (HIE) are variable. Predicting death or severe neurodevelopmental impairment (NDI) in affected neonates is crucial for guiding management and parent communication.

Objective

To predict death or severe NDI in neonates who receive hypothermia for HIE.

Design, setting, and participants

This prognostic study included participants enrolled in a large US clinical trial conducted in US neonatal intensive care units who were born between January 2017 and October 2019 and followed up to age 2 years. Eligible participants were neonates with moderate-severe HIE born at 36 weeks or more gestation and with 2-year outcome data. Data were analyzed June 2023. External validation was performed with a UK cohort.

Exposure

SUBMITTER: Glass HC 

PROVIDER: S-EPMC11621987 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature