Overexpression of HYOU1 is associated with cisplatin resistance and may depend on m⁶A modification in patients with cervical cancer.

ABSTRACT: Cervical cancer (CC) is the fourth leading cause of cancer-associated mortalities among women worldwide. The chemotherapeutical platinum-based agent cisplatin (DDP) is the standard therapy for locally advanced or recurrent CC; however, platinum resistance limits its clinical benefit. Therefore, the present study aimed to identify key genes associated with DDP resistance in patients with CC and investigate the underlying molecular mechanisms. Firstly, using the CRISPR-Cas9 dataset of CC cells derived from DepMap portal, 699 genes associated with CC cell survival were identified. Subsequently, using the gene expression profiles of normal and CC samples with a response status to DDP, derived from The Cancer Genome Atlas (TCGA), hypoxia upregulated 1 (HYOU1) was further identified as si

SUBMITTER: Wang R 

PROVIDER: S-EPMC11622003 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature