Gynecologic tract melanoma in the contemporary therapeutic era: High rates of local and distant disease progression.

ABSTRACT:

Background

Gynecologic tract melanoma (GTM) is a rare malignancy with historically poor outcomes. The current study examines patterns of care and oncologic outcomes in a large single-institution cohort from the contemporary therapeutic era.

Methods

Patterns of care and predictors of outcomes were evaluated for all GTM patients without metastatic disease at diagnosis who were treated at our institution between 2009 and 2020 with >6 months of follow-up.

Results

Of the 124 patients included, anatomic subsites were vulvar (n = 82, 66%), vaginal (n = 34, 27%), or cervical (n = 8, 6%). Primary tumor was resected for 85% (n = 106) with surgical nodal evaluation for 60% (n = 75). Systemic therapy, most commonly immune checkpoint inhibitors (ICI, 58% systemic therapy), was use

SUBMITTER: Mitra D 

PROVIDER: S-EPMC11622147 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature