Longitudinal Changes of Visual Sensitivity With Geographic Atrophy Progression Assessed by Defect-Mapping Microperimetry.

ABSTRACT:

Purpose

To determine the relationship between structural and functional changes over time in the progression of geographic atrophy (GA) as assessed by defect-mapping microperimetry, an approach optimized to characterize the spatial extent of deep visual sensitivity losses.

Methods

A total of 57 eyes from 50 participants underwent defect-mapping microperimetry testing of the central 8° radius (with a 10-dB stimuli presented once each at 208 locations) over a median of five visits, scheduled at 3-monthly intervals. GA lesion(s) on fundus autofluorescence in the corresponding region tested on microperimetry at each visit were manually annotated.

Results

At a global level, change of GA extent in the central 8° radius explained a large proportion of the variance in the cha

SUBMITTER: Saeed A 

PROVIDER: S-EPMC11622159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature