Global functional connectivity reorganization reflects cognitive processing speed deficits and fatigue in multiple sclerosis.

ABSTRACT:

Background and purpose

Cognitive impairment (CI) in multiple sclerosis (MS) is associated with bidirectional changes in resting-state centrality measures. However, practicable functional magnetic resonance imaging (fMRI) biomarkers of CI are still lacking. The aim of this study was to assess the graph-theory-based degree rank order disruption index (k_D) and its association with cognitive processing speed as a marker of CI in patients with MS (PwMS) in a secondary cross-sectional fMRI analysis.

Methods

Differentiation between PwMS and healthy controls (HCs) using k_D and its correlation with CI (Symbol Digit Modalities Test) was compared to established imaging biomarkers (regional degree, volumetry, diffusion-weighted imaging, lesion mapping). Additional

SUBMITTER: Hok P 

PROVIDER: S-EPMC11622266 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature