Low-osmolarity oral rehydration solution for childhood diarrhoea: A systematic review and meta-analysis.

ABSTRACT:

Background

Oral rehydration solution (ORS) is crucial in the management of diarrhoea. Until the early 2000s, the standard formulation of glucose-based ORS with a total osmolarity of 311 mmol/L was being used for this purpose. However, due to concerns about sodium levels and cases of hypernatremia, a low-osmolarity ORS solution (LORS) with an osmolarity of 245mmol/L or less was developed to replace the standard ORS. With this systematic review, we aimed to assess the effectiveness of LORS compared to standard ORS for the treatment of acute and persistent diarrhoea.

Methods

We comprehensively searched PubMed, CINAHL, the Cochrane Library, ClinicalTrials.gov, the World Health Organization (WHO) International Clinical Trials Registry Platform, and Scopus until 20 July 2023 for s

SUBMITTER: Zubairi MBA 

PROVIDER: S-EPMC11622343 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature