Evaluating the efficacy and safety of polyglycolic acid-loading mitomycin nanoparticles in inhibiting the scar proliferation after glaucoma filtering surgery.

ABSTRACT:

Purpose

To prepare a polyglycolic acid-loaded mitomycin drug (MMC-ATS-@PLGA) to inhibit scar proliferation after glaucoma filtering surgery (GFS) via an anti-inflammatory mechanism that minimally affected intraocular pressure, which provided another therapeutic strategy for this disease.

Methods

We first detected the physicochemical properties of MMC-ATS-@PLGA. Next, we tested the biosafety of MMC-ATS-@PLGA in vivo and in vitro. Then, we assessed the therapeutic effects of MMC-ATS-@PLGA by laboratory and clinical examinations.

Results

In this study, we synthesized a new type of nanomedicine (MMC-ATS-@PLGA) with good stability and biocompatibility for inhibiting scar proliferation after GFS. The break-up time (BUT), Schimer test and intraocular pre

SUBMITTER: Li T 

PROVIDER: S-EPMC11622377 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature