Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation.

ABSTRACT: Most neural prosthetic devices are based on electrical stimulation, although the modulation of neuronal activity by a localized chemical delivery would better mimic physiological synaptic machinery. In the past decade, various drug delivery approaches attempted to emulate synaptic transmission, although they were hampered by poor retention of their cargo while reaching the target destination, low spatial resolution, and poor biocompatibility and stability of the materials involved. Here, we propose a planar solid-state device for multisite neurotransmitter translocation at the nanoscale consisting of a nanopatterned ceramic membrane connected to a reservoir designed to store neurotransmitters. We achieved diffusion-mediated glutamate stimulation of primary neurons, while we showed the feas

SUBMITTER: Vacca F 

PROVIDER: S-EPMC11622382 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature