Clinical significance of dynamic monitoring of EVI1 gene expression in pediatric acute myeloid leukemia.

ABSTRACT:

Objective

To investigate the clinical significance of dynamic monitoring ecotropic virus integration site-1 (EVI1) expression in childhood acute myeloid leukemia (AML).

Methods

A retrospective analysis was conducted on 113 pediatric AML patients of Wuhan Children's Hospital from 2014 to 2022. The correlation between EVI1 expression levels and clinical indicators including clinical characteristics, first complete remission (CR1), relapse, and overall survival (OS) was analyzed. Receiver operating characteristic (ROC) curve analysis was carried out to comprehend the influence of EVI1 expression on relapse.

Results

A total of 78 AML children with EVI1 expression at initial diagnosis were eligible, divided into EVI1-positive (EVI1high) and EVI1-negative (EVI1low) groups.

SUBMITTER: Zhang LN 

PROVIDER: S-EPMC11622451 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature