Improving productivity of citramalate from CO₂ by Synechocystis sp. PCC 6803 through design of experiment.

ABSTRACT:

Background

Cyanobacteria have long been suggested as an industrial chassis for the conversion of carbon dioxide to products as part of a circular bioeconomy. The slow growth, carbon fixation rates, and limits of carbon partitioning between biomass and product in cyanobacteria must be overcome to fully realise this industrial potential. Typically, flux towards heterologous pathways is limited by the availability of core metabolites. Citramalate is produced in a single enzymatic step through the condensation of the central metabolites pyruvate and acetyl-CoA; improvements in citramalate productivity can, therefore, be used as a measure of overcoming this limitation. Furthermore, citramalate is a useful biomaterial precursor and provides a route to renewable methyl methacrylate and po

SUBMITTER: Faulkner M 

PROVIDER: S-EPMC11622482 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature