Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia.

ABSTRACT:

Background

Low endogenous immunoglobulin(Ig)-levels are common in critically ill patients with sepsis, but it is unknown whether low Ig-levels are associated with poor outcome, and in which patients Ig-replacement therapy (IgRT) improves outcome. Given the crucial role of immunoglobulins in eliminating certain encapsulated pathogens, we examined the relationship between serial Ig-levels and disease course in critically ill patients with community acquired pneumonia (sCAP) caused by encapsulated or other pathogens.

Methods

We included a cohort of consecutive critically ill patients with CAP, and PaO₂/FiO₂-ratio < 200 with or without septic shock, from an existing biorepository where microbiological causes of infection had been adjudicated in a protocoliz

SUBMITTER: Rademaker E 

PROVIDER: S-EPMC11622494 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature