In vivo and in vitro study on the combination extract of Curcuma zedoaria and Astragalus membranaceus as an adjuvant for PRRSV inactivated vaccine and its preliminary application in piglets.

ABSTRACT:

Background

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a single-stranded positive-sense RNA virus that severely impacts the global swine industry. Recently, variation and recombination of this pathogen have led to more recombinant strains. However, commercial PRRSV vaccines provide limited protection, and no effective therapeutic drugs are available in clinical settings. Astragalus membranaceus (AM) has anti-inflammatory and immune-enhancing properties, while Curcuma zedoaria (CZ) possesses anti-inflammatory, antibacterial, and antitumor effects. The combination of AM and CZ, originating from the "Lichong Tang" recorded in the "Intergrating Chinese and Western Medicine" offers complementary and synergistic benefits.

Methods

In this study, the AM ext

SUBMITTER: Tu T 

PROVIDER: S-EPMC11622496 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature