Characterization of tumor-infiltrating lymphocytes and their spatial distribution in triple-negative breast cancer.

ABSTRACT:

Background

The tumor immune microenvironment, particularly tumor-infiltrating lymphocytes (TILs), plays a critical role in disease progression and treatment response in triple-negative breast cancers (TNBCs). This study was aimed to characterize the composition of TILs and investigate their clinicopathological and prognostic significance with a special focus on the spatial distribution of TILs in TNBCs.

Methods

We analyzed TNBC samples through PanCancer Immune Profiling using NanoString nCounter assays to identify immune-related genes that are expressed differentially in relation to TIL levels and evaluated protein expression of selected markers through immunohistochemical staining on tissue microarrays. For a comprehensive assessment of the expression of cytotoxic T lymphoc

SUBMITTER: Han E 

PROVIDER: S-EPMC11622547 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature