Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health.

ABSTRACT:

Background

Growing evidence suggests that chronic inflammation, resulting from intricate immune system interactions, significantly contributes to the onset of psychiatric disorders. Observational studies have identified a link between immunoglobulin G (IgG) N-glycosylation and various psychiatric conditions, but the causality of these associations remains unclear.

Methods

Genetic variants for IgG N-glycosylation traits and psychiatric disorders were obtained from published genome-wide association studies. The inverse-variance-weighted (IVW) method, MR-Egger, and weighted median were used to estimate causal effects. The Cochran's Q test, MR-Egger intercept test, leave-one-out analyses, and MR-PRESSO global test were used for sensitivity analyses.

Results

In the Psychia

SUBMITTER: Lv Y 

PROVIDER: S-EPMC11622602 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature