EGR1 regulates oral epithelial cell responses to <i>Candida albicans</i> via the EGFR- ERK1/2 pathway.

ABSTRACT: Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C. albicans invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via the action of its peptide toxin candidalysin. However, our knowledge of the epithelial mechanisms involved during C. albicans colonization is rudimentary. Here, we describe the role of the transcription factor early growth response protein 1 (EGR1) in human oral epithelial cells (OECs) in response to C. albicans. EGR1 expression increases in OECs when exposed to C. albicans independently of fungal viability, morphology, or candidalysin release, suggesting EGR1 is involved in the fundamental recognition of

SUBMITTER: Dickenson RE 

PROVIDER: S-EPMC11622614 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature