Blood immune profiling of Ethiopian patients with breast cancer highlights different forms of immune escape.

ABSTRACT: Breast cancer (BC) is a leading cause of death worldwide, particularly also among African woman. In order to better stratify patients for the most effective (immuno-) therapy, an in depth characterization of the immune status of BC patients is required. In this study, a cohort of 65 Ethiopian patients with primary BC underwent immune profiling by multicolor flow cytometry on peripheral blood samples collected prior to surgery and to any other therapy. Comparison with peripheral blood samples from healthy donors highlighted a general activation of the immune system, accompanied by the presence of exhausted CD4⁺ T cells and senescent CD8⁺ T cells with an inverted CD4/CD8 ratio in approximately 50% of BC cases. Enhanced frequencies of γδ T cells, myeloid-derived suppress

SUBMITTER: Yohannes M 

PROVIDER: S-EPMC11622621 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature