Cell-Specific Contribution of IL-4 Receptor α Signaling Shapes the Overall Manifestation of Allergic Airway Disease.

ABSTRACT: IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor IL-4Rα. However, the cell-specific role of IL-4Rα in mixed allergen (MA)-induced allergic asthma has remained unclear. Therefore, we aimed to identify the cell-specific contribution of IL-4Rα signaling in the manifestation of various pathological outcomes in mice with allergic airway disease. We compared MA-induced pathological outcomes between hematopoietic progenitor cell (HPC)- or non-HPC-specific IL-4Rα-deficient chimera, myeloid cell-specific IL-4Rα-deficient (LysMcre^+/+IL-4Rα^fl/fl), and airway epithelial cell-specific IL-4Rα-deficient (CCSP-Cre⁺/IL-4Rα^fl/fl) mice. Chimeric mice with systemic IL-4Rα sufficiency displayed hallmark features of allergi

SUBMITTER: Choudhary I 

PROVIDER: S-EPMC11622633 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature