Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) derived from gestational tissues offer a promising avenue for prenatal intervention in congenital malformations although their application is hampered by concerns related to cellular plasticity and the need for invasive, high-risk surgical procedures. Here, we present naturally occurring exosomes (EXOs) isolated from amniotic fluid-derived MSCs (AF-MSCs) and their mimetic analogs (MIMs) as viable, reproducible, and stable alternatives. These nanovesicles present a minimally invasive therapeutic option, addressing the limitations of MSC-based treatments while retaining therapeutic efficacy.

Methods

MIMs were generated from AF-MSCs by combining sequential filtration steps through filter membranes with different porosity and size exclusi

SUBMITTER: Fonteles CSR 

PROVIDER: S-EPMC11622670 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature